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Blood biomarkers of telltale signs of early Alzheimer’s disease in the brain of his patient, 55-year-old entrepreneur Simon Nicholls, had all but disappeared in a mere 14 months. “I don’t use the term ‘reverse.’ I don’t know what reverse means when it comes to the field of Alzheimer’s,” Isaacson said. ‘It was time to turn to my brain’Slowly, Nicholls’ heart condition began to improve, but the bad news didn’t end there. A brain scan found telltale signs of vascular damage in Nicholls’ brain, which occurs when the tiniest blood vessels are starved of oxygen. Not only was Nicholls blood negative for amyloid and tau, the test suggested that his brain amyloid might be normal, with no distinguishable signs of the disease.
Persons: Sanjay Gupta, Anderson Cooper ”, Richard Isaacson, Simon Nicholls, , , Isaacson, “ Simon, ” Isaacson, Nicholls, ” Nicholls, Anderson Cooper, It’s, APOE4, Simon, ” Simon Nicholls, Sylver, Lewy, Richard Isaacson ‘, APOE ε4, “ I’ve, Isaacson doesn’t, “ I’m, Shocked, Dr, we’d, “ It’s, Salvadore, Richard Isaacson “, ‘ It’s, I’m Organizations: CNN, telltale, ” CNN, Boca Raton Locations: Boca Raton , Florida, New York City, Florida, Nature, Miami, Isaacson’s Florida, tirzepatide
Read previewWarning: Spoilers ahead for "Bridgerton" season three, part one. Fans are lauding season 3 for its representation of people with disabilitiesZak Ford-Williams as Lord Remington on season three of "Bridgerton." — Michelle Birkby (@michelleeb) May 16, 2024Today is Global Accessibility Awareness day and @bridgerton season 3 premier day. Francesca Bridgerton is autistic. Francesca isn't explicitly stated as being on the autism spectrum in Julia Quinn's 'Bridgerton' novels or on the TV seriesHannah Dodd as Francesca Bridgerton on season three, episode two of "Bridgerton."
Persons: , Penelope Featherington, Nicola Coughlan, Colin Bridgerton's, Luke Newton, Francesa Bridgerton, Hannah Dodd, Francesca, Dodd, Jess Brownell, Zak Ford, Williams, Lord Remington, Dolores Stowell, Kitty Devlin, Queen Charlotte, Golda Rosheuvel, Dolores, Lady Stowell, Sophie Woolley, Penelope, Colin ., Whistledown —, Michelle Birkby, — Chanel 🏒, emington,, ady, ord, J, ady V, eason, ord J ohn, ong, ohn, tirling, ove, ike Organizations: Service, Business, Netflix, ust Locations: isible
Significantly less clear, though, is how much the NRA can help Trump’s bid to win the White House once again. “Donald Trump is winning no new voters when he boasts about doing nothing about gun violence during his presidency. Period,” said Nick Suplina, a senior vice president at Everytown for Gun Safety, a group founded in the aftermath of the 2012 Sandy Hook Elementary School shooting. Suplina said Trump’s NRA appearance “shows that both the organization and the man are a bit desperate for each other. Among both gun safety advocates and gun rights groups, there’s little disagreement about the stakes in 2024.
Persons: Donald Trump, Trump, Wayne LaPierre, It’s, , “ It’s, I’ve, ” Trump, Kristi Noem, Donald Trump Jr, Joe Biden’s, Bryan Lanza, “ Donald Trump, ” Lanza, , Biden, Nick Suplina, Sandy, Suplina, Aidan Johnston, Johnston, ” Suplina, ” Biden, Karoline Leavitt, CNN’s Kristen Holmes, Alayna Treene Organizations: Dallas CNN —, National Rifle Association, NRA, White House, New, Political, Mar, CNN, North Dakota Gov, Libertarian Party, Republican, Trump, Biden, Safety, Sandy Hook Elementary, Gun Owners of America, White, U.S Locations: New York, Manhattan, Jersey, Washington ,, Minnesota, United States, Wyoming, Pennsylvania, Parkland , Florida
Read previewFor working mothers, it can sometimes feel like even when there's good news, there's also bad news. Just this week, several stories drove home some of the things that parents and working women already have sensed. But it's a good signal for working moms. The chart shows that since 2015, the percentage of women working across all those groups has gone up in the last 10 years. It's that same mix for the state of working moms — not all good, but not all bad.
Persons: , there's, Emily McCrary, Ruiz, Esparza, Hewlett Packard, That's, it's, Rachel M, Cohen Organizations: Service, Business, Hewlett, Bloomberg, Free, New York Times Reading
What do you know at 17 months old? But back in 2002, at 1.5 years old I knew the perfect color for the family car. My father asked which I liked best, and when I pointed my small toddler finger at the pewter colored car, he was sold. Related storiesThat would be our family car for the next 22 years. Since my brother and I were 17 months old, the pewter colored car held a space in our driveway, and a space in our hearts.
Persons: it's, you've Organizations: Service, GMC Yukon XL
BI spoke to a dozen millennials who have achieved or are on track to achieve financial independence. Brad Barrett, the host of the "ChooseFI" podcast, said "vanishingly few" people with the wherewithal to reach financial independence are retiring early. AdvertisementHe argued that achieving financial independence and hitting a specific number is "the simplest part." Advertisement"I defined myself by the pursuit of financial independence," Sabatier, the author of "Financial Freedom," said. Don't delay figuring out what you really want, why you're pursuing financial independence, and what you want to do after."
Persons: Jace Mattinson, Mattinson, Jace Mattison, Jace Mattison Mattinson, Motley, they're, Millennials, millennials, Scott Rieckens, Brad Barrett, you've, Bill Schaninger, Naina Dhingra, Schaninger, Mitch, , Brian Luebben, Grant Sabatier, Sabina Horrocks, She's, she'd, Michelle Schroeder, Gardner, Wes, I'm, Lauren, Steven Keys, Steven, you'll, We're Organizations: he'd, Business, FIRE, Facebook, McKinsey, FI, Academy, Marketing Locations: Austin, Minnesota
Why Americans might be getting worried about the job marketIn some ways, Americans' growing pessimism in the job market is perplexing. That's because the job market has become more challenging than it was a couple of years ago, when the Great Resignation was at its peak. So, it's possible that some Americans in certain industries are facing a job market where openings are far from abundant. For example, there's some evidence that the job market for high-wage roles has cooled over the past year. Julia Pollak, the chief economist at ZipRecruiter, told Business Insider earlier this month after April's labor market figures were released by the Bureau of Labor Statistics that it is "no longer a white-hot labor market" or a job "candidate's market in every industry where workers can get whatever they want."
Persons: , they'd, hasn't, What's, Joanne Hsu, Julia Pollak Organizations: Service, York Fed's Survey, Consumer, Business, NY, of Labor Statistics, Bureau of Labor Statistics, New, Fed, LinkedIn, NY Fed, University of, Labor Locations: York
For the first few months, we wanted to spend every minute together, excited about this new phase of our relationship. We decided to consciously depersonalize the need to decompress by doing something called "rot time." Meredith Wilshere says her relationship has improved with better communication about the need for alone time. This way, we don't have to feel guilty about taking what we need, when we need it, without feeling like we're neglecting each other. Conversations and communication remain crucial to the health of our relationship, and "rot time" helps us decompress.
Persons: Meredith Wilshere
CNN —Ariff Hassan arrived at the wedding under strict instructions: “Stay away from the bridesmaid.”It was August 2018. “Listen,” said Ariff’s friend. But Ariff’s friend’s warning was ringing round his head. Because Liliya was – of course, inevitably – the bridesmaid Ariff had been warned to stay away from. Ariff Hassan and Liliya DauletaliyevaLiliya and Ariff Kazakhstan wedding celebration incorporated a number of Kazakh traditions.
Persons: CNN — Ariff Hassan, , Ariff, They’d, “ I’d, ‘ I’ve, , Ariff’s, , Liliya Dauletaliyeva, Lili, Liliya, ” Ariff, Ariff Hassan, She’d, she’d, fiancé, who’d, ” Liliya, He’d, “ I’m, , ’ ”, he’d “, ’ ” Ariff, ’ ” Liliya, – she’d, he’d, , that’s, they’re, hadn’t, Ariff shrugged, – Ariff, he’s, you’ve, “ It’s Organizations: CNN, Kazakhstan –, Kuala Lumpur –, CNN Travel, Facebook, Liliya, Malaysian, University of Oxford, Oxford Locations: Singapore, Kazakhstan, Malaysia, Kuala Lumpur, Kazakhstan’s, Almaty, Uzbekistan, Turkmenistan, Liliya, Kazakh, Astana, Iceland, Cappadocia, Turkey, Bangkok, London, , Angkor Wat, Cambodia
Jeff Yang CNNLike its predecessors, GPT-4o is trained on enormous quantities of data to process queries, recognize patterns and deliver helpful responses. Watching the reveal, I found myself involuntarily gasping as researchers Mark Chen and Barret Zoph showed off GPT-4o’s new chops. The freakout aspect of the reveal came from how it demonstrated that GPT-4o isn’t just a tool — it’s a tool with personality. On the one hand, having the option to interrupt your AI chatbot when it’s going astray saves time. On the other, watching dudes repeatedly talking over a female-reading chatbot made it abundantly clear why you can’t spell “mansplain” without AI.
Persons: Jeff Yang, Bruce ”, , Jeff Yang CNN, Mark Chen, Barret Zoph, Chen, Mira Murati, Parmy Olson, , Desi Lydic, , Sam Altman, it’s, Siri, ” chuckling, Altman, Spike Jonze’s, Joaquin Phoenix, Scarlett Johansson, Marc Benioff, Johansson, chatbot, mansplain Organizations: CNN, omni, Zoph . Media, Bloomberg, , Twitter, Boston Dynamics Locations: Asian America, America, omnimodal
The S & P 500 on Wednesday closed above 5,300 for the first time ever. The last time the S & P 500 Short Range Oscillator was this overbought was back in December. The upswing picked up after the S & P 500's most recent bottom on April 19 and pushed to this week's records. .SPX 1Y mountain S & P 500 - 1 year There is no telling whether the current overbought market will follow a similar pattern. Perhaps more telling, four of the bottom six sectors saw earnings estimates revised higher since the end of the first quarter.
Persons: Dow, Morgan Stanley, Stocks, it's, Rather, Jim Cramer's, Jim Cramer, Jim, Victor J Organizations: Federal Reserve, Palo Alto Networks, CNBC, Visitors, New York Stock Exchange, Blue, Bloomberg, Getty
In today's big story, we're looking at how Zyn nicotine pouches are becoming the new weight-loss quick fix . A new weight-loss quick fix is making the rounds just in time for summer's unofficial start (Memorial Day), but this one relies on a highly addictive drug. However, one doctor Hilary spoke to has concerns about the effects of using nicotine to lose weight. Wilson, Amazon, Albany Times Union/Hearst Newspapers/Getty, Creative Crop/Getty, Tyler Le/BIOf course, you don't have to rely on a highly addictive drug to lose weight. Disney CEO Bob Iger said he's giving too much money to the Big Tech app stores that distribute Disney-owned streamers like Hulu and Disney+.
Persons: , Michael M, Rebecca Zisser, Hilary Brueck, Mia de Graaf, Hilary, they're, They're, Wilson, Tyler Le, I'm, BI's Jordan Hart, padel, Gabby Landsverk, Jamie Dimon Jamie Dimon, Jerome Powell, Bob Iger, Bernstein, Rouco, Zers, Dan DeFrancesco, Jordan Parker Erb, Hallam Bullock, George Glover Organizations: Service, HBO, Business, Getty, bros, Albany Times Union, Hearst Newspapers, Creative, CNBC, JPMorgan, GameStop, Disney, Big Tech, Hulu, Google, Big, Microsoft, Wall Street, Citi Locations: Amazon, China, Ireland, Australia, millennials, New York, London
Now that the Dow Jones Industrial Average has made headlines by crossing the 40,000 level for the first time ever on Thursday, what comes next? History shows the 128-year-old-average tends to pull back a bit after crossing large, round number thresholds. "History tends to confirm that the market typically takes a breather after eclipsing millennium milestones." Bear market declines of 20% or more also happened just 5% of the time. .DJI 1Y mountain The 30-stock Dow crossed the 40,000 level on Thursday after flirting with the threshold in April.
Persons: Sam Stovall, Stovall, Dow Organizations: Dow Jones, Dow, Walmart, Nasdaq Locations: 39,8907.88
Advertisement“I pulled up the local news station trying to figure out what was going on, and the first thing I saw was Scottie (Scheffler) had been put in handcuffs,” he said. Sitting in bumper-to-bumper traffic, the Dallas native said he received word that Scheffler’s arrest caused the stoppage. Play eventually was delayed one hour and 20 minutes, to 8:35 a.m.Brian Harman, right, shakes Scottie Scheffler’s hand during their round Friday. “I was a bit shook about what happened on both the scenarios,” Min Woo Lee said of Scheffler’s arrest and Mills’ death. Fans may have focused on Scheffler, but many of the players were equally concerned about Mills and his family.
Persons: — Austin Eckroat, , , Scheffler, John Mills, Bryan Gillis, Gillis, ” Harris, Scottie, , you’ve, Will Zalatoris, Zalatoris, Eckroat, Cameron Young, They’re, ” Zalatoris, Brian Harman, Scottie Scheffler’s, Michael Reaves, Collin Morikawa, Min Woo Lee, Mills, Lee, ” Morikawa, ” Said Mark Hubbard, I’m, That’s, ” Hubbard Organizations: Valhalla Golf, PGA, Rover, Dallas, America, ESPN, Louisville Locations: LOUISVILLE, Ky, Valhalla
Read previewThe first time he saw a short-form video ad made entirely using AI, Will Sartorius thought it was "mind-boggling." Sartorius is the CEO of the agency SelfMade, which works primarily with direct-to-consumer brands on social advertising. In March, Sartorius came across a viral ad in the style of user-generated content that was made using the AI tool Arcads. AdvertisementPatricia Redulla is a user-generated content creator. This includes sentences that warn against using generative AI for anything from idea generation to scripts to editing.
Persons: , Will Sartorius, Sartorius, Ariel Marie, It’s, , — Beck, ike H, ince, ptions, riel, arie, ould, ake, l, ike, ork, eason, anders, arn Organizations: Service, Business Locations: uman
“Maycember” is a term that online content creators the Holderness family coined to describe the sheer chaos of the month of May, much like the month of December. Exhausted teenagers are running on empty as the school year comes to an end, while expectations of parental involvement remain high. I’m always grateful for the people who volunteer their time to head up committees on the PTA or parent board. Prioritize mental healthNo good comes from a family running around from event to event without a moment even to enjoy the ones they attend. In a few short weeks, Maycember will be behind us for another year, and we’ll all breathe a sigh of relief.
Persons: , Holderness, it’s, I’ve, there’s, I’m, you’ll, It’s, Maycember, You’ll, Katie Hurley, Strong, Fiona McPhee Organizations: CNN
Read previewAfter one week of jury selection and four weeks of prosecution testimony, Donald Trump's New York hush-money trial is now in its home stretch. Then, the defense case will begin. "I'm doing everything possible to avoid big breaks between summations, jury charge, jury instructions, and deliberations," Merchan told the parties Thursday. AP/Christine CornellThursday: Deliberations could beginAgain, if the scheduling stars align, deliberations could begin Thursday, the last trial day before the four-day holiday. AdvertisementBefore deliberations can begin, jurors need to hear the entirety of the defense case — with or without Trump.
Persons: , Donald Trump's, Juan Merchan, Trump, Michael Cohen, Donald Trump, Julia Nikhinson, Cohen, Trump's, Todd Blanche, Susan Hoffinger, Blanche, — Bradley, Smith, Juan Merchan Jane Rosenberg, Christopher Conroy, Merchan's, Conroy, Merchan, Will Trump, Matt Gaetz, Mike Segar, Judge Cannon, Aileen Cannon, Christine Cornell Organizations: Service, Business, AP, Commission, Prosecutors, Reuters, Federal Election, Trump Locations: York, Florida, summations
As they were originally conceived, Disney's international parks were meant to "bring the unforgettable Disney magic to an international audience," according to the company. While the international parks themselves have always taken steps to accommodate diverse audiences — providing shows and attractions in multiple languages — Disney appears to be marketing the international parks to American audiences in more direct ways. In addition to the content creator efforts, Disney has begun to include its international parks in its own content consumed by Americans. In the Disney+ show "Behind the Attraction," which premiered in 2021, numerous variations on American rides at international parks were discussed and digested for American audiences. Disney creators around the world grew their followings, and demand for content from international Disney parks rose alongside them.
Persons: Peter Pan, Disney, Quincy Stanford, AllEars, Stanford, Emma Kenner, Kenner, Taylor Swift, Rolling Stone Organizations: Disney, Tokyo Disney, YouTube, Disney Parks, NBC, Tokyo Disneyland, Magic, Tokyo Disney Resort, Stanford, Walt Disney Co, Paris La Défense, Rolling, Swift Locations: China, Japan, Tokyo, Shanghai, Hong Kong, U.S, California, Florida, Tokyo ., Paris
Season three of "Bridgerton" centers on Polin, the ship name of Penelope Featherington (Nicola Coughlan) and Colin Bridgerton (Luke Newton). Nicola Coughlan as Penelope Featherington and Luke Newton as Colin Bridgerton on season three of "Bridgerton." AdvertisementClaudia Jessie as Eloise Bridgerton and Hannah Dodd as Francesca Bridgerton on season three, episode three of "Bridgerton." AdvertisementLuke Thompson as Benedict Bridgerton on season three, episode two of "Bridgerton." "Bridgerton" season three, part one is now streaming on Netflix.
Persons: Penelope Featherington, Nicola Coughlan, Colin Bridgerton, Luke Newton, Colin, Penelope, Whistledown —, Jess Brownell, Coughlan, Newton, Kate, Anthony Bridgerton, Laurence Cendrowicz, Luke Newton's, Erika Okvist, she's, Nicola, Liam Daniel, Penelope's, Mister Bridgerton, Bridgerton, Portia, Luke, There's, there's, Rhimes, they're, Eloise, Whistledown, Claudia Jessie, Eloise Bridgerton, Hannah Dodd, Francesca Bridgerton, Anthony, they'll, Jonathan Bailey, Simone Ashley, Cressida, She's, Benedict, Tilly Arnold, Luke Thompson, Benedict Bridgerton, Charlotte, Lady, Danbury's, Violet, Marcus Anderson, Marcus, she'll, we've, they've Organizations: Service, Netflix, Business, Lady Danbury Locations: Polin, That's, Danbury, Violet
Mortgage interest rates have moved lower amid signs that persistently high inflation may be starting to cool. The 10-year Treasury yield fell following the release of this data, and mortgage rates followed suit. Once inflation slows enough that the Federal Reserve is able to start lowering the federal funds rate, mortgage rates and other consumer rates should trend down. See more mortgage rates on Zillow Real Estate on ZillowToday's refinance ratesMortgage type Average rate today This information has been provided by Zillow. This means your entire monthly mortgage payment, including taxes and insurance, shouldn't exceed 28% of your pre-tax monthly income.
Persons: you'll, Fannie Mae Organizations: of Labor Statistics, Treasury, Federal Reserve, Investors, Zillow, Mortgage, Association, Sky Locations: Chevron
Every weekday, the CNBC Investing Club with Jim Cramer releases the Homestretch — an actionable afternoon update, just in time for the last hour of trading on Wall Street. Market wrap: It's day two of muted action in the market, which was trading in a tight range on a light news day to close out the week. As a subscriber to the CNBC Investing Club with Jim Cramer, you will receive a trade alert before Jim makes a trade. THE ABOVE INVESTING CLUB INFORMATION IS SUBJECT TO OUR TERMS AND CONDITIONS AND PRIVACY POLICY , TOGETHER WITH OUR DISCLAIMER . NO FIDUCIARY OBLIGATION OR DUTY EXISTS, OR IS CREATED, BY VIRTUE OF YOUR RECEIPT OF ANY INFORMATION PROVIDED IN CONNECTION WITH THE INVESTING CLUB.
Persons: Jim Cramer, we're, OpenAI, Deere, Ralph Lauren, Jim Cramer's, Jim Organizations: CNBC, Tech, Devices, Broadcom, Nvidia, Microsoft, Palo Alto Networks, Palo, Walmart, TJX, Target, Williams, Coterra Energy, Jim Cramer's Charitable Locations: Palo Alto, Sonoma, Truist
Share Share Article via Facebook Share Article via Twitter Share Article via LinkedIn Share Article via EmailChina's April retail sales data 'a little bit of a blip,' economist saysLouise Loo of Oxford Economics says, however, that a "mild improvement" in consumer confidence can be expected.
Persons: Louise Loo Organizations: Oxford Economics
Trump’s Criminal Trial, Explained
  + stars: | 2024-05-17 | by ( Jonah E. Bromwich | ) www.nytimes.com   time to read: +2 min
Stormy Daniels was on the witness stand, Donald Trump was at the defense table and I could feel a queasy energy flow through the Manhattan courtroom. This is the third of Trump’s trials that I’ve covered, but there’s still something striking about seeing a ubiquitous media figure in the flesh. Trump is not on trial for sleeping with Daniels, which he denies, or for paying her to keep silent. Even though it’s a documents case, the trial has thrummed with high-octane moments like his face-off with Daniels. Each time the prosecution calls a witness, rows of onlookers watch a figure from Trump’s past swear an oath that could threaten his future.
Persons: Stormy Daniels, Donald Trump, Daniels, I’ve, Trump, it’s Organizations: Trump, Prosecutors Locations: Manhattan, today’s
Walmart keeps posting strong earnings, driven in part by gains among higher-income shoppers. Bit by bit, Walmart is looking more like Target, and that should terrify the smaller rival. Sign up to get the inside scoop on today’s biggest stories in markets, tech, and business — delivered daily. download the app Email address Sign up By clicking “Sign Up”, you accept our Terms of Service and Privacy Policy . The Bentonville retailer on Thursday reported a solid 6% year-over-year improvement in first-quarter sales, with profits growing even faster.
Persons: , Doug McMillon Organizations: Walmart, Service, Business Locations: Bentonville
Sam Altman throws shade at Google's 'aesthetic'
  + stars: | 2024-05-16 | by ( Ana Altchek | ) www.businessinsider.com   time to read: +1 min
OpenAI and Google each held major events this week announcing AI updates, one day apart. Sam Altman said he "cannot stop thinking" about the aesthetic difference between Google and OpenAI. The post led a Google engineer to call out Altman for timing OpenAI's event just before Google's. AdvertisementSam Altman isn't afraid to stir the pot a bit in the AI race, and his latest post took aim at Google. OpenAI and Google held their biggest events of the year so far, a day apart from each other — and AI was the theme of both.
Persons: Sam Altman, Altman, , Sam Altman isn't, OpenAI Organizations: Google, Service, Astra, Business
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